Ilrun | inflammation and lipid regulator with UBA-like and NBR1-like domains
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Behavior/neurological
13 No significant impact
3 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased startle reflex | 1 supporting dataset | IlrunGt(IST12471H5)Tigm | homozygote | Early adult | 4.01x10-6 | ||
| abnormal uterus morphology | 1 supporting dataset | IlrunGt(IST12471H5)Tigm | homozygote | Early adult | N/A * | ||
| decreased lean body mass | 2 supporting datasets | Ilrunem1(IMPC)Tcp | homozygote | Early adult | 3.93x10-5 | ||
| abnormal spleen morphology | 2 supporting datasets | IlrunGt(IST12471H5)Tigm | homozygote | Early adult | N/A * | ||
| small spleen | 2 supporting datasets | IlrunGt(IST12471H5)Tigm | homozygote | Early adult | N/A * | ||
| small seminal vesicle | 1 supporting dataset | IlrunGt(IST12471H5)Tigm | homozygote | Early adult | N/A * | ||
| small uterus | 1 supporting dataset | IlrunGt(IST12471H5)Tigm | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 2 supporting datasets | Ilrunem1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| impaired glucose tolerance | 1 supporting dataset | Ilrunem1(IMPC)Tcp | homozygote | Early adult | 2.52x10-7 | ||
| increased spleen weight | 1 supporting dataset | IlrunGt(IST12471H5)Tigm | homozygote | Early adult | 7.67x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (3/3) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 75% (3/4) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (4/4) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (4/4) | 0.56% (3/532) |
Human diseases caused by Ilrun mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ilrun.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| IlrunGt(IST12471H5)Tigm | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ilrunem1(IMPC)Tcp | Exon Deletion | | mouse |
| Ilruntm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ilruntm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |