Cdc42 | cell division cycle 42

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Skeleton Mortality/aging Craniofacial Renal/urinary system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

3Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased hemoglobin content	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.67x10^-9
increased circulating HDL cholesterol level	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.46x10^-5
increased circulating cholesterol level	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.49x10^-6
abnormal retina morphology	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.65x10^-9
abnormal cranium morphology	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.04x10^-5
increased red blood cell distribution width	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.38x10^-6
enlarged kidney	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.53x10^-5
increased lymphocyte cell number	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.12x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Cdc42.

Associated images

Loading...

Histopathology

There is no histopathology data found for Cdc42.

IMPC related publications

Loading...

External links

No external links available for Cdc42.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Cdc42^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cdc42^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cdc42^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cdc42^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Cdc42^{tm536(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes