Cdc42 | cell division cycle 42
GeneMGI:106211
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Skeleton Mortality/aging Craniofacial Renal/urinary system
11 No significant impact
4 Not tested
Data collections
Gene metrics:18Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| decreased hemoglobin content | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.67x10-9 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.46x10-5 | ||
| increased circulating cholesterol level | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.49x10-6 | ||
| abnormal retina morphology | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.65x10-9 | ||
| abnormal cranium morphology | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.04x10-5 | ||
| increased red blood cell distribution width | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.38x10-6 | ||
| enlarged kidney | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.53x10-5 | ||
| increased lymphocyte cell number | 1 supporting dataset | Cdc42tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.12x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Cdc42 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cdc42.
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| Cdc42tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cdc42tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cdc42tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cdc42tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Cdc42tm536(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |