Cdc42 | cell division cycle 42

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Skeleton Mortality/aging Craniofacial Renal/urinary system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

3Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased hemoglobin content	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.67x10^-9
increased circulating HDL cholesterol level	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.46x10^-5
increased circulating cholesterol level	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.49x10^-6
abnormal retina morphology	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.65x10^-9
abnormal cranium morphology	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.04x10^-5
increased red blood cell distribution width	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.38x10^-6
enlarged kidney	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.53x10^-5
increased lymphocyte cell number	1 supporting dataset	Cdc42^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.12x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cdc42.

Associated images

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Histopathology

There is no histopathology data found for Cdc42.

IMPC related publications

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External links

No external links available for Cdc42.

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*Cdc42^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cdc42^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cdc42^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cdc42^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Cdc42^{tm536(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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