Hells | helicase, lymphoid specific

GeneMGI:106209Synonyms: LSH, Lysh, +4 more

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased cardiac stroke volume	1 supporting dataset	Hells^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.63x10^-11
abnormal gait	1 supporting dataset	Hells^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.85x10^-7
increased CD8-positive, alpha-beta T cell number	1 supporting dataset	Hells^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.29x10^-5
dilated heart left ventricle	2 supporting datasets	Hells^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.36x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Hells^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Hells^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.19x10^-7
decreased monocyte cell number	1 supporting dataset	Hells^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.74x10^-6
decreased circulating cholesterol level	1 supporting dataset	Hells^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.59x10^-5
decreased circulating triglyceride level	1 supporting dataset	Hells^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.13x10^-9
decreased circulating LDL cholesterol level	1 supporting dataset	Hells^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.52x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hells.

Associated images

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Histopathology

There is no histopathology data found for Hells.

IMPC related publications

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External links

No external links available for Hells.

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*Hells^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hells^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hells^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Hells^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Hells^{tm44592(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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