Cyp7a1 | cytochrome P450, family 7, subfamily a, polypeptide 1

GeneMGI:106091Synonyms: cholesterol 7 alpha hydroxylase

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.88x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.69x10^-9
decreased exploration in new environment	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.43x10^-5
abnormal lens morphology	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.76x10^-7
abnormal retina vasculature morphology	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.29x10^-6
abnormal retina morphology	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.03x10^-8
increased startle reflex	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.6x10^-6
increased circulating unsaturated transferrin level	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.97x10^-8
decreased circulating iron level	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.35x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Cyp7a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.08x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cyp7a1.

Associated images

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Histopathology

There is no histopathology data found for Cyp7a1.

IMPC related publications

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External links

No external links available for Cyp7a1.

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*Cyp7a1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cyp7a1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cyp7a1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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