Cfb | complement factor B

GeneMGI:105975Synonyms: alternative-complement pathway C3/C5 convertase, FB, +4 more

Physiological systems

22 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Renal/urinary system

19 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

4Associated diseases

Expression examined in:52Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



increased hematocrit	1 supporting dataset	Cfb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.78x10^-5
increased erythrocyte cell number	1 supporting dataset	Cfb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	5.06x10^-9
abnormal kidney morphology	1 supporting dataset	Cfb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating phosphate level	1 supporting dataset	Cfb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	4.91x10^-6
increased fasting circulating glucose level	1 supporting dataset	Cfb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	3.2x10^-7
increased hemoglobin content	1 supporting dataset	Cfb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.12x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Cfb.

Associated images

Loading...

Histopathology

There is no histopathology data found for Cfb.

IMPC related publications

Loading...

External links

No external links available for Cfb.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Cfb^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cfb^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Cfb^{tm1.1(KOMP)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Cfb^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cfb^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Cfb^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cfb^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes