Txlna | taxilin alpha
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Behavior/neurological Mortality/aging
11 No significant impact
6 Not tested
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| small testis | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased large unstained cell number | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.56x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.41x10-7 | ||
| increased lymphocyte cell number | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.94x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.71x10-7 | ||
| increased large unstained cell number | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.02x10-6 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal gait | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.91x10-5 | ||
| increased circulating potassium level | 1 supporting dataset | Txlnatm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.45x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Txlna mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Txlna.
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| Txlnatm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Txlnatm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Txlnatm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |