Mpp1 | membrane protein, palmitoylated
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Growth/size/body region Vision/eye Respiratory system Hematopoietic system
16 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased T-helper cell number | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | 3.35x10-6 | ||
| enlarged lymph nodes | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased CD4-positive, alpha-beta T cell number | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | 6.52x10-6 | ||
| abnormal eye morphology | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| anophthalmia | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased effector memory T-helper cell number | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | 2.66x10-5 | ||
| enlarged spleen | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased effector memory T-helper cell number | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | 3.42x10-5 | ||
| decreased lung elastance | 1 supporting dataset | Mpp1em1(IMPC)Ccpcz | homozygote | Early adult | 1.56x10-6 |
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Human diseases caused by Mpp1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mpp1.
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| Mpp1em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Mpp1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Mpp1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |