Rab5c | RAB5C, member RAS oncogene family

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Mortality/aging

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating total protein level1 supporting datasetRab5ctm1a(EUCOMM)WtsiheterozygoteEarly adult3.79x10-7 
increased circulating fructosamine level1 supporting datasetRab5ctm1a(EUCOMM)WtsiheterozygoteEarly adult1.71x10-7 
decreased circulating cholesterol level1 supporting datasetRab5ctm1a(EUCOMM)WtsiheterozygoteEarly adult9.02x10-5 
preweaning lethality, complete penetrance1 supporting datasetRab5ctm1a(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased circulating alkaline phosphatase level1 supporting datasetRab5ctm1a(EUCOMM)WtsiheterozygoteEarly adult2.71x10-10 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rab5ctm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Rab5ctm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Rab5ctm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell

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