Satb1 | special AT-rich sequence binding protein 1
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Hearing/vestibular/ear Vision/eye Behavior/neurological Skeleton Mortality/aging
14 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
3Associated diseases
Expression examined in:48Adult tissues
0Embryo tissues
| hyperactivity | 4 supporting datasets | Satb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.66x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Satb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.63x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Satb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal vitreous body morphology | 1 supporting dataset | Satb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1x10-6 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Satb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.28x10-5 | ||
| abnormal bone structure | 1 supporting dataset | Satb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.81x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Satb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.6x10-5 | ||
| increased exploration in new environment | 1 supporting dataset | Satb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.34x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Satb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Satb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Satb1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Satb1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Satb1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Satb1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Satb1tm83411(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Satb1tm83411(L1L2_gt1_Del_LacZ) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |