Slc9a4 | solute carrier family 9 (sodium/hydrogen exchanger), member 4
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Behavior/neurological Skeleton
13 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased bone mineral density | 1 supporting dataset | Slc9a4tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.16x10-10 | ||
| decreased prepulse inhibition | 1 supporting dataset | Slc9a4tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.91x10-5 | ||
| increased circulating cholesterol level | 1 supporting dataset | Slc9a4tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.9x10-5 | ||
| decreased startle reflex | 1 supporting dataset | Slc9a4tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.41x10-6 | ||
| decreased bone mineral content | 2 supporting datasets | Slc9a4tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.78x10-12 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 50% (1/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Slc9a4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc9a4.
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| Slc9a4tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc9a4tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |