Lepr | leptin receptor

GeneMGI:104993Synonyms: OB-RGRP, leptin receptor gene-related protein, +6 more

Physiological systems

17 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

6 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:48Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased lean body mass	2 supporting datasets	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.18x10^-142
abnormal locomotor behavior	1 supporting dataset	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.05x10^-15
increased mean corpuscular hemoglobin	1 supporting dataset	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.31x10^-5
increased circulating cholesterol level	1 supporting dataset	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.3x10^-128
increased circulating total protein level	1 supporting dataset	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.3x10^-23
trunk curl	1 supporting dataset	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.18x10^-23
decreased spleen weight	1 supporting dataset	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7x10^-35
decreased bone mineral content	2 supporting datasets	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.29x10^-55
impaired righting response	1 supporting dataset	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.41x10^-22
enlarged liver	2 supporting datasets	Lepr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lepr.

Associated images

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Histopathology

There is no histopathology data found for Lepr.

IMPC related publications

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External links

No external links available for Lepr.

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*Lepr^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Lepr^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Lepr^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lepr^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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