Gclc | glutamate-cysteine ligase, catalytic subunit

GeneMGI:104990Synonyms: Glclc, D9Wsu168e, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

4Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased lean body mass	1 supporting dataset	Gclc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.64x10^-7
decreased circulating calcium level	1 supporting dataset	Gclc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.8x10^-5
decreased total body fat amount	1 supporting dataset	Gclc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.86x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gclc.

Associated images

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Histopathology

There is no histopathology data found for Gclc.

IMPC related publications

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External links

No external links available for Gclc.

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*Gclc^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Gclc^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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