Ddx6 | DEAD-box helicase 6

GeneMGI:104976Synonyms: p54, mRCK/P54, +6 more

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Ddx6^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Ddx6^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal neural tube morphology	1 supporting dataset	Ddx6^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Ddx6^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
increased circulating total protein level	1 supporting dataset	Ddx6^em1(IMPC)Mbp	heterozygote	Early adult	4.99x10^-5
abnormal skin morphology	1 supporting dataset	Ddx6^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Ddx6^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal embryo turning	1 supporting dataset	Ddx6^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Ddx6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Ddx6^em1(IMPC)Mbp	heterozygote	Early adult	5.4x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ddx6.

Associated images

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Histopathology

There is no histopathology data found for Ddx6.

IMPC related publications

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External links

No external links available for Ddx6.

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*Ddx6^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ddx6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ddx6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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