Ppox | protoporphyrinogen oxidase
GeneMGI:104968
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Hearing/vestibular/ear Mortality/aging
13 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating phosphate level | 1 supporting dataset | Ppoxem1(IMPC)J | heterozygote | Early adult | 1.99x10-8 | ||
| embryonic growth retardation | 1 supporting dataset | Ppoxem1(IMPC)J | homozygote | E9.5 | N/A * | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Ppoxem1(IMPC)J | heterozygote | Early adult | 2.84x10-8 | ||
| abnormal auditory brainstem response | 2 supporting datasets | Ppoxem1(IMPC)J | heterozygote | Early adult | 1.6x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Ppoxem1(IMPC)J | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Ppoxem1(IMPC)J | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ppoxem1(IMPC)J | homozygote | Early adult | N/A * |
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Human diseases caused by Ppox mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ppox.
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| Ppoxem1(IMPC)J | Exon Deletion | | mouse |
| Ppoxtm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ppoxtm459307(Ifitm2_intron_L1L2_GT2_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |