Tnfaip1 | tumor necrosis factor, alpha-induced protein 1 (endothelial)

GeneMGI:104961Synonyms: Edp1, Edp-1, +2 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Behavior/neurological Skeleton

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased grip strength	4 supporting datasets	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.18x10^-7
increased startle reflex	1 supporting dataset	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.12x10^-5
increased bone mineral density	1 supporting dataset	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.53x10^-9
short tibia	2 supporting datasets	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.51x10^-5
abnormal bone mineralization	1 supporting dataset	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.56x10^-5
increased circulating glucose level	1 supporting dataset	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.5x10^-5
abnormal tail movements	1 supporting dataset	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.29x10^-5
increased blood urea nitrogen level	1 supporting dataset	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.3x10^-5
increased total body fat amount	1 supporting dataset	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.16x10^-9
increased circulating alkaline phosphatase level	1 supporting dataset	Tnfaip1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.66x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tnfaip1.

Associated images

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Histopathology

There is no histopathology data found for Tnfaip1.

IMPC related publications

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External links

No external links available for Tnfaip1.

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*Tnfaip1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Tnfaip1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tnfaip1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Tnfaip1^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Tnfaip1^{tm9(L1L2_st2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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