Akt2 | thymoma viral proto-oncogene 2

GeneMGI:104874Synonyms: 2410016A19Rik, PKBbeta, +1 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Skeleton

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased bone mineral content	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	8.38x10^-5
abnormal glucose homeostasis	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	3.2x10^-8
increased circulating alkaline phosphatase level	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	2.2x10^-15
decreased circulating triglyceride level	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	1.05x10^-21
increased lean body mass	1 supporting dataset	Akt2^tm1Wcs	heterozygote	Early adult	6.83x10^-14
abnormal bone structure	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	2.14x10^-6
abnormal bone mineralization	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	9.06x10^-15
increased circulating calcium level	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	3.58x10^-5
thrombocytosis	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	7.94x10^-5
increased lean body mass	1 supporting dataset	Akt2^tm1Wcs	homozygote	Early adult	4.98x10^-18

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Akt2.

Associated images

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Histopathology

There is no histopathology data found for Akt2.

IMPC related publications

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External links

No external links available for Akt2.

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*Akt2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Akt2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Akt2^{tm40417(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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