Osm | oncostatin M

GeneMGI:104749Synonyms: OncoM

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Skeleton Cardiovascular system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular hemoglobin	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.34x10^-26
increased mean corpuscular volume	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.42x10^-18
decreased circulating free fatty acids level	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.2x10^-5
increased bone mineral content	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.86x10^-5
increased heart weight	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.89x10^-6
decreased erythrocyte cell number	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.85x10^-13
thrombocytopenia	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.69x10^-13
decreased hematocrit	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.34x10^-6
decreased hemoglobin content	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.8x10^-7
decreased circulating glucose level	1 supporting dataset	Osm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.27x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Osm.

Associated images

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Histopathology

There is no histopathology data found for Osm.

IMPC related publications

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External links

No external links available for Osm.

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*Osm^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Osm^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Osm^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Osm^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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