Osm | oncostatin M
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Skeleton Cardiovascular system
12 No significant impact
7 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
50Embryo tissues
| increased mean corpuscular hemoglobin | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 1.34x10-26 | ||
| increased mean corpuscular volume | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 4.42x10-18 | ||
| decreased circulating free fatty acids level | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 3.2x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 2.86x10-5 | ||
| increased heart weight | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 6.89x10-6 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 2.85x10-13 | ||
| thrombocytopenia | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 1.69x10-13 | ||
| decreased hematocrit | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 1.34x10-6 | ||
| decreased hemoglobin content | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 4.8x10-7 | ||
| decreased circulating glucose level | 1 supporting dataset | Osmtm1b(KOMP)Wtsi | homozygote | Early adult | 5.27x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
Human diseases caused by Osm mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Osm.
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| Osmtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Osmtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Osmtm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Osmtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |