Cdkn2a | cyclin dependent kinase inhibitor 2A

GeneMGI:104738Synonyms: ARF-INK4a, INK4a-ARF, +8 more

Physiological systems

19 / 24 physiological systems tested

1 Significantly impacted by the knock-out

Vision/eye

18 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

11Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes



abnormal eye morphology	2 supporting datasets	Cdkn2a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.8x10^-7
cataract	1 supporting dataset	Cdkn2a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.82x10^-6
abnormal lens morphology	1 supporting dataset	Cdkn2a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.82x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cdkn2a.

Associated images

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Histopathology

There is no histopathology data found for Cdkn2a.

IMPC related publications

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External links

No external links available for Cdkn2a.

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*Cdkn2a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cdkn2a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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