Cct3 | chaperonin containing TCP1 subunit 3

GeneMGI:104708Synonyms: Cctg, TriC-P5, +1 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased mean corpuscular hemoglobin1 supporting datasetCct3em1(IMPC)TcpheterozygoteEarly adult5.48x10-6 
increased startle reflex1 supporting datasetCct3em1(IMPC)TcpheterozygoteEarly adult1.49x10-8 
preweaning lethality, complete penetrance3 supporting datasetsCct3em1(IMPC)TcphomozygoteEarly adultN/A * 
increased mean platelet volume1 supporting datasetCct3em1(IMPC)TcpheterozygoteEarly adult3.06x10-30 
embryonic lethality prior to organogenesis1 supporting datasetCct3em1(IMPC)TcphomozygoteE9.5N/A * 
prolonged QT interval1 supporting datasetCct3em1(IMPC)TcpheterozygoteEarly adult6.42x10-5 
decreased exploration in new environment1 supporting datasetCct3em1(IMPC)TcpheterozygoteEarly adult9.27x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cct3em1(IMPC)TcpExon Deletionmouse
Cct3tm119383(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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