Scnn1b | sodium channel, nonvoltage-gated 1 beta

GeneMGI:104696Synonyms: ENaC beta

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Skeleton Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

6Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal pelvic girdle bone morphology	1 supporting dataset	Scnn1b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.25x10^-5
increased circulating fructosamine level	1 supporting dataset	Scnn1b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.06x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Scnn1b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Scnn1b.

Associated images

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Histopathology

There is no histopathology data found for Scnn1b.

IMPC related publications

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External links

No external links available for Scnn1b.

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*Scnn1b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Scnn1b^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Scnn1b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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