Twist2 | twist basic helix-loop-helix transcription factor 2

GeneMGI:104685Synonyms: bHLHa39, Dermo1

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Growth/size/body region Respiratory system Mortality/aging

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

6Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal testis morphology	1 supporting dataset	Twist2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
enlarged lung	1 supporting dataset	Twist2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Twist2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
increased lung weight	1 supporting dataset	Twist2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.97x10^-6
preweaning lethality, incomplete penetrance	3 supporting datasets	Twist2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal lung morphology	1 supporting dataset	Twist2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Twist2.

Associated images

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Histopathology

There is no histopathology data found for Twist2.

IMPC related publications

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External links

No external links available for Twist2.

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*Twist2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Twist2^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Twist2^{tm415683(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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