Man2a1 | mannosidase 2, alpha 1

GeneMGI:104669Synonyms: Mana2, Mana-2, +1 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Cardiovascular system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



thrombocytopenia	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	3.21x10^-5
abnormal vitreous body morphology	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.54x10^-5
increased red blood cell distribution width	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	7.02x10^-24
increased mean platelet volume	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	2.32x10^-6
increased heart weight	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	2.34x10^-5
abnormal cecum morphology	2 supporting datasets	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	N/A ^*
decreased blood urea nitrogen level	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.6x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	3.79x10^-18
decreased circulating calcium level	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	4.07x10^-5
decreased circulating iron level	1 supporting dataset	Man2a1^{em1(IMPC)Hmgu}	homozygote	Early adult	7.48x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Man2a1.

Associated images

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Histopathology

There is no histopathology data found for Man2a1.

IMPC related publications

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External links

No external links available for Man2a1.

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*Man2a1^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Man2a1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Man2a1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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