Lep | leptin
GeneMGI:104663
Physiological systems
17 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Reproductive system Immune system Integument Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
8 No significant impact
7 Not tested
Data collections
Gene metrics:18Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues
decreased locomotor activity | 3 supporting datasets | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.89x10-8 | ||
prolonged QRS complex duration | 1 supporting dataset | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.81x10-6 | ||
abnormal coat appearance | 2 supporting datasets | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.84x10-5 | ||
decreased spleen weight | 1 supporting dataset | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.84x10-9 | ||
increased cornea thickness | 1 supporting dataset | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.11x10-5 | ||
decreased total retina thickness | 2 supporting datasets | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.54x10-5 | ||
decreased grip strength | 4 supporting datasets | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.68x10-47 | ||
decreased heart rate | 1 supporting dataset | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.89x10-5 | ||
increased cardiac stroke volume | 1 supporting dataset | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.59x10-6 | ||
short tibia | 1 supporting dataset | Leptm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.14x10-61 |
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External links
No external links available for Lep.
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Leptm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Leptm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Leptm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |