Lep | leptin

Physiological systems

17 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Immune system Integument Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

2Associated diseases

Expression examined in:51Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	3 supporting datasets	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.89x10^-8
prolonged QRS complex duration	1 supporting dataset	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.81x10^-6
abnormal coat appearance	2 supporting datasets	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.84x10^-5
decreased spleen weight	1 supporting dataset	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.84x10^-9
increased cornea thickness	1 supporting dataset	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.11x10^-5
decreased total retina thickness	2 supporting datasets	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.54x10^-5
decreased grip strength	4 supporting datasets	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.68x10^-47
decreased heart rate	1 supporting dataset	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.89x10^-5
increased cardiac stroke volume	1 supporting dataset	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.59x10^-6
short tibia	1 supporting dataset	Lep^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.14x10^-61

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lep.

Associated images

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Histopathology

There is no histopathology data found for Lep.

IMPC related publications

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External links

No external links available for Lep.

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*Lep^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Lep^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lep^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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