Lep | leptin

Physiological systems

17 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Reproductive system Immune system Integument Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

7 Not tested

Gene metrics:18Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues

Phenotypes

decreased locomotor activity3 supporting datasetsLeptm1b(EUCOMM)HmguhomozygoteEarly adult2.89x10-8 
prolonged QRS complex duration1 supporting datasetLeptm1b(EUCOMM)HmguhomozygoteEarly adult9.81x10-6 
abnormal coat appearance2 supporting datasetsLeptm1b(EUCOMM)HmguhomozygoteEarly adult2.84x10-5 
decreased spleen weight1 supporting datasetLeptm1b(EUCOMM)HmguhomozygoteEarly adult4.84x10-9 
increased cornea thickness1 supporting datasetLeptm1b(EUCOMM)HmguhomozygoteEarly adult6.11x10-5 
decreased total retina thickness2 supporting datasetsLeptm1b(EUCOMM)HmguhomozygoteEarly adult8.54x10-5 
decreased grip strength4 supporting datasetsLeptm1b(EUCOMM)HmguhomozygoteEarly adult6.68x10-47 
decreased heart rate1 supporting datasetLeptm1b(EUCOMM)HmguhomozygoteEarly adult2.89x10-5 
increased cardiac stroke volume1 supporting datasetLeptm1b(EUCOMM)HmguhomozygoteEarly adult2.59x10-6 
short tibia1 supporting datasetLeptm1b(EUCOMM)HmguhomozygoteEarly adult3.14x10-61 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Leptm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Leptm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Leptm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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