Wars1 | tryptophanyl-tRNA synthetase1

GeneMGI:104630Synonyms: Wars

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Muscle Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

4Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal lens morphology	3 supporting datasets	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.02x10^-11
decreased mean corpuscular volume	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.46x10^-13
abnormal liver morphology	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
decreased cardiac muscle contractility	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.85x10^-7
abnormal gait	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	7.68x10^-5
polycystic kidney	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.82x10^-6
enlarged liver	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.63x10^-5
abnormal kidney morphology	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wars1.

Associated images

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Histopathology

There is no histopathology data found for Wars1.

IMPC related publications

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External links

No external links available for Wars1.

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*Wars1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Wars1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Wars1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Wars1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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