Wars1 | tryptophanyl-tRNA synthetase1

GeneMGI:104630Synonyms: Wars

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Muscle Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

4Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal lens morphology	3 supporting datasets	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.02x10^-11
decreased mean corpuscular volume	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.46x10^-13
abnormal liver morphology	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
decreased cardiac muscle contractility	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.85x10^-7
abnormal gait	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	7.68x10^-5
polycystic kidney	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.82x10^-6
enlarged liver	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.63x10^-5
abnormal kidney morphology	1 supporting dataset	Wars1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Wars1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Wars1.

IMPC related publications

Loading...

External links

No external links available for Wars1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Wars1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Wars1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Wars1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Wars1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes