Dst | dystonin
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Embryo Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Cardiovascular system
15 No significant impact
3 Not tested
Gene metrics:5Significant phenotypes
4Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues
| abnormal embryo size | 1 supporting dataset | Dsttm1b(EUCOMM)Wtsi | heterozygote | E18.5 | N/A * | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Dsttm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Dsttm1b(EUCOMM)Wtsi | heterozygote | E12.5 | N/A * | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Dsttm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.42x10-5 | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Dsttm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Dsttm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.44x10-6 | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Dsttm1b(EUCOMM)Wtsi | heterozygote | E18.5 | N/A * |
| | | | | | | | | | |
External links
No external links available for Dst.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Dsttm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dsttm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dsttm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |