Cnr1 | cannabinoid receptor 1

GeneMGI:104615Synonyms: CB1R, CB1

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Behavior/neurological Mortality/aging

18 No significant impact

2 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
30Embryo tissues

Phenotypes

decreased thigmotaxis2 supporting datasetsCnr1tm1.1(KOMP)VlcgheterozygoteEarly adult2.39x10-40 
abnormal skin morphology1 supporting datasetCnr1tm1.1(KOMP)VlcgheterozygoteEarly adultN/A * 
hyperactivity5 supporting datasetsCnr1tm1.1(KOMP)VlcgheterozygoteEarly adult5.55x10-41 
abnormal behavior1 supporting datasetCnr1tm1.1(KOMP)VlcgheterozygoteEarly adult2.39x10-40 
edema1 supporting datasetCnr1tm1.1(KOMP)VlcgheterozygoteE15.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetCnr1tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
edema1 supporting datasetCnr1tm1.1(KOMP)VlcghomozygoteE15.5N/A * 
preweaning lethality, incomplete penetrance2 supporting datasetsCnr1tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cnr1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Cnr1tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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