Eps15 | epidermal growth factor receptor pathway substrate 15
Physiological systems
20 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Hematopoietic system
19 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased mean corpuscular volume | 1 supporting dataset | Eps15tm1a(KOMP)Wtsi | homozygote | Early adult | 2.63x10-10 | ||
| decreased hemoglobin content | 1 supporting dataset | Eps15tm1a(KOMP)Wtsi | homozygote | Early adult | 3.08x10-5 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Eps15tm1a(KOMP)Wtsi | homozygote | Early adult | 6.42x10-17 |
| | | | | | | | | | |
| adrenal gland | homozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | homozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | homozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | homozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | homozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | homozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | homozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | homozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | homozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | homozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Eps15 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Eps15.
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| Eps15tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Eps15tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Eps15tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Eps15tm357289(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |