Gnb4 | guanine nucleotide binding protein (G protein), beta 4
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
11 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased grip strength | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Early adult | 1.31x10-5 | ||
| enlarged spleen | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Early adult | N/A * | ||
| decreased thigmotaxis | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Late adult | 9.65x10-5 | ||
| abnormal behavior | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Late adult | 9.65x10-5 | ||
| decreased anxiety-related response | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Late adult | 1.99x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Late adult | 4.93x10-8 | ||
| hyperactivity | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Late adult | 5.25x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Late adult | 4.83x10-5 | ||
| enlarged heart | 1 supporting dataset | Gnb4em1(IMPC)H | homozygote | Early adult | N/A * |
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External links
No external links available for Gnb4.
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| Gnb4em1(IMPC)H | Exon Deletion | | mouse |
| Gnb4tm1aNarl | KO first allele (reporter-tagged insertion with conditional potential) | | ES Cell mouse |
| Gnb4tm39537(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |