Hcls1 | hematopoietic cell specific Lyn substrate 1

GeneMGI:104568Synonyms: HS1

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Hematopoietic system Renal/urinary system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



enlarged spleen	2 supporting datasets	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
absent optic nerve	1 supporting dataset	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased kidney weight	1 supporting dataset	Hcls1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.84x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hcls1.

Associated images

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Histopathology

There is no histopathology data found for Hcls1.

IMPC related publications

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External links

No external links available for Hcls1.

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*Hcls1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Hcls1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Hcls1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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