Fgd1 | FYVE, RhoGEF and PH domain containing 1

GeneMGI:104566Synonyms: ZFYVE3, faciogenital dysplasia

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Endocrine/exocrine gland Embryo Growth/size/body region Vision/eye Hematopoietic system Craniofacial

13 No significant impact

3 Not tested

Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal embryo size1 supporting datasetFgd1em1(IMPC)TcphemizygoteE15.5N/A * 
abnormal craniofacial morphology1 supporting datasetFgd1em1(IMPC)TcpheterozygoteE15.5N/A * 
microphthalmia1 supporting datasetFgd1em1(IMPC)TcphemizygoteE15.5N/A * 
edema1 supporting datasetFgd1em1(IMPC)TcphemizygoteE15.5N/A * 
abnormal craniofacial morphology1 supporting datasetFgd1em1(IMPC)TcphemizygoteE15.5N/A * 
embryonic growth retardation1 supporting datasetFgd1em1(IMPC)TcphemizygoteE15.5N/A * 
enlarged thymus1 supporting datasetFgd1em1(IMPC)TcpheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Fgd1em1(IMPC)TcpExon Deletionmouse
Fgd1tm47889(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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