Myo7a | myosin VIIA
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Skeleton
16 No significant impact
3 Not tested
Data collections
Gene metrics:12Significant phenotypes
7Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased blood urea nitrogen level | 1 supporting dataset | Myo7atm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.22x10-5 | ||
| absent pinna reflex | 1 supporting dataset | Myo7atm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.05x10-18 | ||
| impaired righting response | 1 supporting dataset | Myo7atm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.38x10-8 | ||
| increased lean body mass | 1 supporting dataset | Myo7aHdb | homozygote | Early adult | 1.47x10-11 | ||
| abnormal locomotor activation | 1 supporting dataset | Myo7aHdb | homozygote | Early adult | 5.49x10-7 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Myo7atm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.21x10-5 | ||
| stereotypic behavior | 1 supporting dataset | Myo7atm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.56x10-16 | ||
| increased circulating sodium level | 1 supporting dataset | Myo7atm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.21x10-6 | ||
| trunk curl | 1 supporting dataset | Myo7atm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.01x10-20 | ||
| decreased body weight | 1 supporting dataset | Myo7aHdb | homozygote | Early adult | 4.31x10-34 |
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Human diseases caused by Myo7a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Myo7a.
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| Myo7ash1-6J | | ES Cell | |
| Myo7atm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Myo7atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Myo7atm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Myo7atm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Myo7atm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |