Myo7a | myosin VIIA

GeneMGI:104510Synonyms: Hdb, nmf371, +3 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Skeleton

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased blood urea nitrogen level	1 supporting dataset	Myo7a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.22x10^-5
absent pinna reflex	1 supporting dataset	Myo7a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.05x10^-18
impaired righting response	1 supporting dataset	Myo7a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.38x10^-8
increased lean body mass	1 supporting dataset	Myo7a^Hdb	homozygote	Early adult	1.47x10^-11
abnormal locomotor activation	1 supporting dataset	Myo7a^Hdb	homozygote	Early adult	5.49x10^-7
persistence of hyaloid vascular system	1 supporting dataset	Myo7a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.21x10^-5
stereotypic behavior	1 supporting dataset	Myo7a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.56x10^-16
increased circulating sodium level	1 supporting dataset	Myo7a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.21x10^-6
trunk curl	1 supporting dataset	Myo7a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.01x10^-20
decreased body weight	1 supporting dataset	Myo7a^Hdb	homozygote	Early adult	4.31x10^-34

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Myo7a.

Associated images

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Histopathology

There is no histopathology data found for Myo7a.

IMPC related publications

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External links

No external links available for Myo7a.

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*Myo7a^sh1-6J*		‌	ES Cell
*Myo7a^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Myo7a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Myo7a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Myo7a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Myo7a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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