Tyro3 | TYRO3 protein tyrosine kinase 3

GeneMGI:104294Synonyms: Sky, Dtk, +4 more

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Vision/eye Respiratory system Hematopoietic system Skeleton Cardiovascular system Craniofacial

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased eosinophil cell number	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.92x10^-5
abnormal thymus morphology	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal digit morphology	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.82x10^-8
enlarged heart	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.34x10^-5
abnormal lymph node morphology	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal tooth morphology	1 supporting dataset	Tyro3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Tyro3.

Associated images

Loading...

Histopathology

There is no histopathology data found for Tyro3.

IMPC related publications

Loading...

External links

No external links available for Tyro3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Tyro3^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Tyro3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Tyro3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Tyro3^{tm33622(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes