Kpna2 | karyopherin subunit alpha 2

GeneMGI:103561Synonyms: pendulin, Rch1, +5 more

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal testis morphology	1 supporting dataset	Kpna2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
male infertility	1 supporting dataset	Kpna2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal cholesterol homeostasis	1 supporting dataset	Kpna2^em1(IMPC)Mbp	heterozygote	Late adult	1.33x10^-5
no spontaneous movement	1 supporting dataset	Kpna2^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
no spontaneous movement	1 supporting dataset	Kpna2^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
decreased locomotor activity	2 supporting datasets	Kpna2^em1(IMPC)Mbp	heterozygote	Early adult	1.05x10^-7
preweaning lethality, incomplete penetrance	3 supporting datasets	Kpna2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Kpna2^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
female infertility	1 supporting dataset	Kpna2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Kpna2^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kpna2.

Associated images

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Histopathology

There is no histopathology data found for Kpna2.

IMPC related publications

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External links

No external links available for Kpna2.

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*Kpna2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Kpna2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Kpna2^{tm210408(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

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