Kpna2 | karyopherin subunit alpha 2
Physiological systems
22 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system
13 No significant impact
2 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal testis morphology | 1 supporting dataset | Kpna2em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| male infertility | 1 supporting dataset | Kpna2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Kpna2em1(IMPC)Mbp | heterozygote | Late adult | 1.33x10-5 | ||
| no spontaneous movement | 1 supporting dataset | Kpna2em1(IMPC)Mbp | heterozygote | E18.5 | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Kpna2em1(IMPC)Mbp | homozygote | E18.5 | N/A * | ||
| decreased locomotor activity | 2 supporting datasets | Kpna2em1(IMPC)Mbp | heterozygote | Early adult | 1.05x10-7 | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Kpna2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small kidney | 1 supporting dataset | Kpna2em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| female infertility | 1 supporting dataset | Kpna2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Kpna2em1(IMPC)Mbp | heterozygote | Late adult | N/A * |
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Human diseases caused by Kpna2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Kpna2.
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| Kpna2em1(IMPC)Mbp | Exon Deletion | | mouse |
| Kpna2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Kpna2tm210408(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |