Sox18 | SRY (sex determining region Y)-box 18

GeneMGI:103559Synonyms: Sry-related HMG-box gene 18, Ragl

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

3Associated diseases

Expression examined in:49Adult tissues

51Embryo tissues

Phenotypes

Phy. System:



decreased thigmotaxis	2 supporting datasets	Sox18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.5x10^-6
increased circulating sodium level	1 supporting dataset	Sox18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.6x10^-5
abnormal behavior	1 supporting dataset	Sox18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.5x10^-6
increased mean corpuscular hemoglobin	1 supporting dataset	Sox18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.47x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Sox18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.82x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sox18.

Associated images

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Histopathology

There is no histopathology data found for Sox18.

IMPC related publications

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External links

No external links available for Sox18.

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*Sox18^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Sox18^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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