Apobec1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal heart morphology	1 supporting dataset	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased startle reflex	1 supporting dataset	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.23x10^-6
abnormal spleen morphology	2 supporting datasets	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal digit morphology	1 supporting dataset	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.23x10^-6
abnormal skin morphology	1 supporting dataset	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	2 supporting datasets	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	2 supporting datasets	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Apobec1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Apobec1.

Associated images

16 images

X-ray

XRay Images Forepaw

32 images

X-ray

XRay Images Hind Leg and Hip

16 images

X-ray

XRay Images Skull Dorso Ventral Orientation

16 images

X-ray

XRay Images Skull Lateral Orientation

32 images

X-ray

XRay Images Whole Body Dorso Ventral

16 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Apobec1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Apobec1.

IMPC related publications

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External links

No external links available for Apobec1.

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*Apobec1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Apobec1^{tm42782(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes

Apobec1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Physiological systems

9 Significantly impacted by the knock-out

13 No significant impact

2 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

X-ray

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Apobec1 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data