Apobec1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal heart morphology1 supporting datasetApobec1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
decreased startle reflex1 supporting datasetApobec1em1(IMPC)CcpczhomozygoteEarly adult3.23x10-6 
abnormal spleen morphology2 supporting datasetsApobec1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
enlarged heart1 supporting datasetApobec1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
enlarged spleen2 supporting datasetsApobec1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal digit morphology1 supporting datasetApobec1em1(IMPC)CcpczhomozygoteEarly adult3.23x10-6 
abnormal skin morphology1 supporting datasetApobec1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal thymus morphology2 supporting datasetsApobec1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
enlarged thymus2 supporting datasetsApobec1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal testis morphology1 supporting datasetApobec1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Apobec1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Apobec1em1(IMPC)CcpczExon Deletionmouse
Apobec1tm42782(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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