Atp6v0a1 | ATPase, H+ transporting, lysosomal V0 subunit A1
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Skeleton Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
29Embryo tissues
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Atp6v0a1tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| increased circulating potassium level | 1 supporting dataset | Atp6v0a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.1x10-18 | ||
| increased bone mineral content | 1 supporting dataset | Atp6v0a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.93x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Atp6v0a1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Atp6v0a1tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| decreased total body fat amount | 2 supporting datasets | Atp6v0a1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.52x10-7 |
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Human diseases caused by Atp6v0a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Atp6v0a1.
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| Atp6v0a1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Atp6v0a1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Atp6v0a1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |