Aqp1 | aquaporin 1

GeneMGI:103201Synonyms: CHIP28

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased circulating amylase level	1 supporting dataset	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	3.03x10^-7
decreased locomotor activity	6 supporting datasets	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	1.65x10^-9
impaired glucose tolerance	1 supporting dataset	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.39x10^-5
decreased locomotor activity	7 supporting datasets	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.47x10^-15
decreased bone mineral content	2 supporting datasets	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.45x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.15x10^-32
decreased total body fat amount	1 supporting dataset	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	1.37x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.07x10^-6
decreased grip strength	2 supporting datasets	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.21x10^-9
increased lean body mass	1 supporting dataset	Aqp1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	2.17x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aqp1.

Associated images

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Histopathology

There is no histopathology data found for Aqp1.

IMPC related publications

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External links

No external links available for Aqp1.

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*Aqp1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Aqp1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Aqp1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Aqp1^{tm44540(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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