Spr | sepiapterin reductase

GeneMGI:103078

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased grip strength	1 supporting dataset	Spr^em1(IMPC)H	heterozygote	Early adult	3.82x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Spr^em1(IMPC)H	homozygote	Early adult	N/A ^*
increased neutrophil cell number	1 supporting dataset	Spr^em1(IMPC)H	heterozygote	Early adult	2.61x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Spr.

Associated images

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Histopathology

There is no histopathology data found for Spr.

IMPC related publications

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External links

No external links available for Spr.

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*Spr^em1(IMPC)H*	Inter-exon deletion	‌	mouse
*Spr^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Spr^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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