Vdr | vitamin D (1,25-dihydroxyvitamin D3) receptor

GeneMGI:103076Synonyms: Nr1i1

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Pigmentation Immune system Integument Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal coat/hair pigmentation	5 supporting datasets	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	1.64x10^-7
decreased startle reflex	1 supporting dataset	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	4.34x10^-5
abnormal gait	1 supporting dataset	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	4.63x10^-7
decreased locomotor activity	5 supporting datasets	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	1.05x10^-6
abnormal head morphology	1 supporting dataset	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	6.64x10^-9
tremors	1 supporting dataset	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	6.13x10^-5
decreased bone mineral content	2 supporting datasets	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	0
decreased bone mineral density	1 supporting dataset	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	0
abnormal bone structure	1 supporting dataset	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	0
abnormal locomotor behavior	1 supporting dataset	Vdr^{em1(IMPC)Hmgu}	homozygote	Early adult	3.07x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Vdr.

Associated images

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Histopathology

There is no histopathology data found for Vdr.

IMPC related publications

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External links

No external links available for Vdr.

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*Vdr^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Vdr^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Vdr^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Vdr^{tm44836(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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