Epb41l1 | erythrocyte membrane protein band 4.1 like 1
Physiological systems
17 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Skeleton Cardiovascular system
9 No significant impact
7 Not tested
Data collections
Gene metrics:16Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| increased lean body mass | 1 supporting dataset | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.11x10-7 | ||
| improved glucose tolerance | 2 supporting datasets | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.54x10-7 | ||
| decreased grip strength | 2 supporting datasets | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.34x10-12 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.77x10-5 | ||
| hyperactivity | 10 supporting datasets | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.55x10-31 | ||
| increased startle reflex | 1 supporting dataset | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.8x10-6 | ||
| abnormal iris pigmentation | 1 supporting dataset | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.62x10-7 | ||
| abnormal locomotor behavior | 1 supporting dataset | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.39x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.65x10-5 | ||
| decreased thigmotaxis | 2 supporting datasets | Epb41l1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.27x10-5 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | n/a | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Epb41l1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Epb41l1.
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| Epb41l1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Epb41l1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Epb41l1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |