Srprb | signal recognition particle receptor, B subunit
GeneMGI:102964
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| decreased mean corpuscular volume | 1 supporting dataset | Srprbtm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.41x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Srprbtm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased circulating creatinine level | 1 supporting dataset | Srprbtm2b(EUCOMM)Hmgu | heterozygote | Early adult | 2.06x10-7 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Srprbtm2b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Srprbtm2b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Srprb mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Srprb.
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| Srprbtm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Srprbtm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Srprbtm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |