Ube2a | ubiquitin-conjugating enzyme E2A

GeneMGI:102959Synonyms: HR6A, HHR6A

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:98Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased locomotor activity	1 supporting dataset	Ube2a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.18x10^-5
female infertility	1 supporting dataset	Ube2a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
hyperactivity	1 supporting dataset	Ube2a^{tm1.1(KOMP)Vlcg}	hemizygote	Early adult	8.35x10^-5
increased heart weight	1 supporting dataset	Ube2a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.25x10^-6
decreased circulating serum albumin level	1 supporting dataset	Ube2a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.99x10^-9
abnormal retina blood vessel morphology	1 supporting dataset	Ube2a^{tm1.1(KOMP)Vlcg}	hemizygote	Early adult	6.71x10^-5
increased startle reflex	1 supporting dataset	Ube2a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.44x10^-8
decreased grip strength	1 supporting dataset	Ube2a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.63x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ube2a.

Associated images

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Histopathology

There is no histopathology data found for Ube2a.

IMPC related publications

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External links

No external links available for Ube2a.

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*Ube2a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Ube2a^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Ube2a^{tm88303(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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