Elk4 | ELK4, member of ETS oncogene family

GeneMGI:102853Synonyms: 2310011G17Rik, Sap1, +1 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Skeleton Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:26Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased bone mineral content	1 supporting dataset	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.03x10^-6
abnormal bone structure	1 supporting dataset	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.1x10^-6
cornea opacity	1 supporting dataset	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.72x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.71x10^-5
decreased circulating glycerol level	1 supporting dataset	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.47x10^-6
increased circulating sodium level	1 supporting dataset	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.18x10^-5
decreased circulating triglyceride level	2 supporting datasets	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.85x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.27x10^-9
decreased circulating cholesterol level	2 supporting datasets	Elk4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.56x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Elk4.

Associated images

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Histopathology

There is no histopathology data found for Elk4.

IMPC related publications

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External links

No external links available for Elk4.

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*Elk4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Elk4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Elk4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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