Sars1 | seryl-tRNA synthetase 1

GeneMGI:102809Synonyms: Strs, Sars

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Vision/eye Behavior/neurological Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

3Associated diseases

Expression examined in:49Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased grip strength	2 supporting datasets	Sars1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	6.32x10^-5
abnormal iris pigmentation	1 supporting dataset	Sars1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.25x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Sars1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
improved glucose tolerance	1 supporting dataset	Sars1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.18x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Sars1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sars1.

Associated images

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Histopathology

There is no histopathology data found for Sars1.

IMPC related publications

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External links

No external links available for Sars1.

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*Sars1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Sars1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Sars1^{tm405(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes