Acvr2a | activin receptor IIA

GeneMGI:102806Synonyms: Acvr2, tActRII, +1 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Embryo Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Craniofacial

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:43Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	2 supporting datasets	Acvr2a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Acvr2a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal behavior	1 supporting dataset	Acvr2a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.04x10^-5
abnormal embryo size	1 supporting dataset	Acvr2a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
anophthalmia	1 supporting dataset	Acvr2a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
decreased neutrophil cell number	1 supporting dataset	Acvr2a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.4x10^-7
increased thigmotaxis	2 supporting datasets	Acvr2a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.04x10^-5
decreased eosinophil cell number	2 supporting datasets	Acvr2a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.15x10^-5
abnormal craniofacial morphology	1 supporting dataset	Acvr2a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Acvr2a.

Associated images

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Histopathology

There is no histopathology data found for Acvr2a.

IMPC related publications

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External links

No external links available for Acvr2a.

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*Acvr2a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Acvr2a^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Acvr2a^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Acvr2a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Acvr2a^{tm270449(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Acvr2a^{tm378905(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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