Prss2 | serine protease 2
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Behavior/neurological Skeleton
12 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| limb grasping | 1 supporting dataset | Prss2tm1.1(KOMP)Vlcg | homozygote | Late adult | 6.81x10-8 | ||
| decreased bone mineral content | 2 supporting datasets | Prss2tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.39x10-7 | ||
| decreased circulating phosphate level | 1 supporting dataset | Prss2tm1.1(KOMP)Vlcg | homozygote | Late adult | 7.49x10-5 | ||
| impaired righting response | 1 supporting dataset | Prss2tm1.1(KOMP)Vlcg | homozygote | Late adult | 2.36x10-7 | ||
| decreased locomotor activity | 1 supporting dataset | Prss2tm1.1(KOMP)Vlcg | homozygote | Late adult | 7.7x10-5 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Prss2tm1.1(KOMP)Vlcg | homozygote | Late adult | 1.5x10-5 | ||
| decreased bone mineral density | 1 supporting dataset | Prss2tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.59x10-6 | ||
| increased exploration in new environment | 1 supporting dataset | Prss2tm1.1(KOMP)Vlcg | homozygote | Late adult | 2.12x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Prss2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Prss2.
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| Prss2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Prss2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Prss2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Prss2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |