Tbx4 | T-box 4

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Embryo Growth/size/body region Mortality/aging

16 No significant impact

5 Not tested

Gene metrics:7Significant phenotypes
6Associated diseases
Expression examined in:42Adult tissues
29Embryo tissues

Phenotypes

pale yolk sac1 supporting datasetTbx4tm4b(EUCOMM)WtsihomozygoteE12.5N/A * 
embryonic lethality prior to tooth bud stage1 supporting datasetTbx4tm4b(EUCOMM)WtsihomozygoteE12.5N/A * 
abnormal embryo size1 supporting datasetTbx4tm4b(EUCOMM)WtsihomozygoteE12.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetTbx4tm4b(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tbx4tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Tbx4tm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
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Tbx4tm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell
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Tbx4tm4a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
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Tbx4tm4b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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