Cpe | carboxypeptidase E

GeneMGI:101932Synonyms: NF-alpha1, carboxypeptidase H, +3 more

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:24Significant phenotypes

2Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	5 supporting datasets	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.51x10^-12
increased circulating alkaline phosphatase level	1 supporting dataset	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.44x10^-11
decreased grip strength	2 supporting datasets	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.08x10^-14
decreased vertical activity	1 supporting dataset	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.54x10^-10
decreased food intake	1 supporting dataset	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.79x10^-7
increased fasting circulating glucose level	1 supporting dataset	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.51x10^-14
decreased circulating chloride level	1 supporting dataset	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.92x10^-9
increased thigmotaxis	2 supporting datasets	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.87x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	0
increased circulating glucose level	1 supporting dataset	Cpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.18x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cpe.

Associated images

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Histopathology

There is no histopathology data found for Cpe.

IMPC related publications

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External links

No external links available for Cpe.

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*Cpe^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cpe^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cpe^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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