Ap2a1 | adaptor-related protein complex 2, alpha 1 subunit

GeneMGI:101921Synonyms: Adtaa

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Hematopoietic system Behavior/neurological

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating creatinine level	1 supporting dataset	Ap2a1^em1(IMPC)J	homozygote	Early adult	3.54x10^-6
abnormal vocalization	1 supporting dataset	Ap2a1^em1(IMPC)J	homozygote	Early adult	1.04x10^-6
decreased mean corpuscular hemoglobin	1 supporting dataset	Ap2a1^em1(IMPC)J	homozygote	Early adult	0
hyperactivity	5 supporting datasets	Ap2a1^em1(IMPC)J	homozygote	Early adult	4.31x10^-8
abnormal coat/hair pigmentation	1 supporting dataset	Ap2a1^em1(IMPC)J	heterozygote	Early adult	1.2x10^-9
abnormal vocalization	1 supporting dataset	Ap2a1^em1(IMPC)J	heterozygote	Early adult	2.42x10^-10
decreased mean corpuscular volume	1 supporting dataset	Ap2a1^em1(IMPC)J	homozygote	Early adult	5.54x10^-12
abnormal coat/hair pigmentation	1 supporting dataset	Ap2a1^em1(IMPC)J	homozygote	Early adult	7.02x10^-8
improved glucose tolerance	1 supporting dataset	Ap2a1^em1(IMPC)J	homozygote	Early adult	2.31x10^-5
decreased grip strength	2 supporting datasets	Ap2a1^em1(IMPC)J	heterozygote	Early adult	4.61x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ap2a1.

Associated images

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Histopathology

There is no histopathology data found for Ap2a1.

IMPC related publications

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External links

No external links available for Ap2a1.

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*Ap2a1^em1(IMPC)J*	Exon Deletion	‌	mouse
*Ap2a1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ap2a1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ap2a1^{tm290088(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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