Ap2a2 | adaptor-related protein complex 2, alpha 2 subunit

GeneMGI:101920Synonyms: alpha-adaptin C, alpha-C adaptin, +3 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased circulating cholesterol level	1 supporting dataset	Ap2a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
increased circulating LDL cholesterol level	1 supporting dataset	Ap2a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
decreased circulating serum albumin level	1 supporting dataset	Ap2a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
increased circulating LDL cholesterol level	1 supporting dataset	Ap2a2^{em1(IMPC)Wtsi}	heterozygote	Early adult	2.8x10^-8
absent pinna reflex	1 supporting dataset	Ap2a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.26x10^-9
preweaning lethality, incomplete penetrance	1 supporting dataset	Ap2a2^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Ap2a2^{em1(IMPC)Wtsi}	heterozygote	Early adult	6.4x10^-5
increased circulating iron level	1 supporting dataset	Ap2a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.06x10^-6
increased circulating free fatty acids level	1 supporting dataset	Ap2a2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.14x10^-7
decreased circulating fructosamine level	1 supporting dataset	Ap2a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ap2a2.

Associated images

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Histopathology

There is no histopathology data found for Ap2a2.

IMPC related publications

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External links

No external links available for Ap2a2.

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*Ap2a2^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Ap2a2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Ap2a2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ap2a2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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